Nobel Prize

Nobel Prize

Nobel Prize Nobel Prize in Physiology or Medicine 2012


The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings have revolutionised our understanding of how cells and organisms develop.

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Sir John B. Gurdon

Sir John B. Gurdon

Born: 1933, Dippenhall, United Kingdom

Affiliation at the time of the award: Gurdon Institute, Cambridge, United Kingdom

Prize motivation: "for the discovery that mature cells can be reprogrammed to become pluripotent


The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles

Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes.

Histone variant macroH2A confers resistance to nuclear reprogramming.

Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?

Shinya Yamanaka

Shinya Yamanaka


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