TB bacteria use iron to survive
the tuberculosis (tb) bacteria kill two people every three minutes. The bacteria uses iron from the human body to survive. But the mechanism by which they source the iron was not known. Researchers from the University of Hyderabad have recently cracked the mechanism. Their research paves the way for new medicines to treat the disease better.
The tb pathogen sources its iron through molecules called siderophores, which have high affinity for iron. First, the pathogens release these molecules, which extracts iron from human cells, leaving them iron-scarce. The molecules are then transported back to the pathogen, which synthesizes the iron to sustain and grow at the cost of the host. These actions are dependent on two proteins that help complete the transportation cycle of siderophores. Blocking this transportation through medicines can be a breakthrough to cure tb. First, it will stop the iron uptake and secretion. Since there will be no export pathway for siderophores, it will extract iron from the microbe itself.